Sesalac Cave is 17 km from Sokobanja, 46 km from Aleksinac, 80 km from Niš, and 245 km from Belgrade. The easiest way to reach the site is from the regional road Sokobanja–Knjaževac, turning north near Čitluk toward the villages of Sesalac and Milušinac, then at the intersection turning left through the village of Sesalac.